The Chemistry of AspirinAspirin, one of the first drugs to come into common usage, is still mostly the widely used in the world - approximately 35,000 metric tonnes are produced and consumed annually, enough to make over 100 billion standard aspirin tablets every year.
Aspirin, also known as 'acetylsalicylic acid', has a chemical formula of C9H8O4.
Aspirin, also known as 'acetylsalicylic acid', has a chemical formula of C9H8O4.
The chemical structure of aspirin:
Aspirin, is analgesic, anti-inflammatory, antipyretic and is an inhibitor of platelet aggregation. It inhibits fatty acid cyclo-oxygenase by acetylation of the active site of enzyme and the pharmacological effects of aspirin are due to the inhibition of the formation of cyclo-oxygenase products including prostglandins, thromboxanes and prostacyclin.
Aspirin is prepared by chemical synthesis from salicylic acid, by acetylation with acetic anhydride.
Aspirin is prepared by chemical synthesis from salicylic acid, by acetylation with acetic anhydride.
Reactions
Raw Materials
Phenol C6H5-OH
Sodium Hydroxide NaOH
Carbon Dioxide CO2
Acetic Anhydride CH3COOCOCH3
Hydrogen H
The Reactions
The production of aspirin from raw materials can be divided into four separate reactions. These are shown below:
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